Dra. Lisette Rondón Medrano

Ciencia

La ciencia del rejuvenecimiento

AL ALCANCE DE TUS MANOS

PUBLICACIONES CIENTÍFICAS

1. Jin K, Simpkins JW, Ji X, Leis M, Stambler I. The critical need to promote research of aging and aging-related diseases to improve health and longevity of the elderly population. Aging Dis. 2014; 6:1–5. https://doi.org/10.14336/AD.2014.1210 [PubMed]

2. Sen P, Shah PP, Nativio R, Berger SL. Epigenetic mechanisms of longevity and aging. Cell. 2016; 166:822–39. https://doi.org/10.1016/j.cell.2016.07.050 [PubMed]

5. Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018; 19:371–84. https://doi.org/10.1038/s41576-018-0004-3 [PubMed]

6. Field AE, Robertson NA, Wang T, Havas A, Ideker T, Adams PD. DNA methylation clocks in aging: categories, causes, and consequences. Mol Cell. 2018; 71:882–95. https://doi.org/10.1016/j.molcel.2018.08.008 [PubMed]

7. Johnson AA, Akman K, Calimport SR, Wuttke D, Stolzing A, de Magalhães JP. The role of DNA methylation in aging, rejuvenation, and age-related disease. Rejuvenation Res. 2012; 15:483–94. https://doi.org/10.1089/rej.2012.1324 [PubMed]

8. Mitteldorf JJ. How does the body know how old it is? introducing the epigenetic clock hypothesis. Biochemistry (Mosc). 2013; 78:1048–53. https://doi.org/10.1134/S0006297913090113 [PubMed]

9. Rando TA, Chang HY. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell. 2012; 148:46–57. https://doi.org/10.1016/j.cell.2012.01.003 [PubMed]

10. Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013; 14:R115. https://doi.org/10.1186/gb-2013-14-10-r115 [PubMed]

11. Langie SA, Moisse M, Declerck K, Koppen G, Godderis L, Vanden Berghe W, Drury S, De Boever P. Salivary DNA methylation profiling: aspects to consider for biomarker identification. Basic Clin Pharmacol Toxicol. 2017 (Suppl 3); 121:93–101. https://doi.org/10.1111/bcpt.12721 [PubMed]

12. Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, et al. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging (Albany NY). 2017; 9:419–46. https://doi.org/10.18632/aging.101168 [PubMed]

13. Hore TA. Modulating epigenetic memory through vitamins and TET: implications for regenerative medicine and cancer treatment. Epigenomics. 2017; 9:863–71. https://doi.org/10.2217/epi-2017-0021 [PubMed]

14. Arora I, Sharma M, Tollefsbol TO. Combinatorial epigenetics impact of polyphenols and phytochemicals in cancer prevention and therapy. Int J Mol Sci. 2019; 20:4567. https://doi.org/10.3390/ijms20184567 [PubMed]

15. Sybesma W, Starrenburg M, Tijsseling L, Hoefnagel MH, Hugenholtz J. Effects of cultivation conditions on folate production by lactic acid bacteria. Appl Environ Microbiol. 2003; 69:4542–48. https://doi.org/10.1128/aem.69.8.4542-4548.2003 [PubMed]

16. Hariri M, Salehi R, Feizi A, Mirlohi M, Ghiasvand R, Habibi N. A randomized, double-blind, placebo-controlled, clinical trial on probiotic soy milk and soy milk: effects on epigenetics and oxidative stress in patients with type II diabetes. Genes Nutr. 2015; 10:52. https://doi.org/10.1007/s12263-015-0503-1 [PubMed]

17. Ren H, Collins V, Clarke SJ, Han JS, Lam P, Clay F, Williamson LM, Andy Choo KH. Epigenetic changes in response to tai chi practice: a pilot investigation of DNA methylation marks. Evid Based Complement Alternat Med. 2012; 2012:841810. https://doi.org/10.1155/2012/841810 [PubMed]

18. White AJ, Sandler DP, Bolick SC, Xu Z, Taylor JA, DeRoo LA. Recreational and household physical activity at different time points and DNA global methylation. Eur J Cancer. 2013; 49:2199–206. https://doi.org/10.1016/j.ejca.2013.02.013 [PubMed]

19. e Silva Ade S, da Mota MP. Effects of physical activity and training programs on plasma homocysteine levels: a systematic review. Amino Acids. 2014; 46:1795–804. https://doi.org/10.1007/s00726-014-1741-z [PubMed]

20. Spólnicka M, Pośpiech E, Adamczyk JG, Freire-Aradas A, Pepłońska B, Zbieć-Piekarska R, Makowska Ż, Pięta A, Lareu MV, Phillips C, Płoski R, Żekanowski C, Branicki W. Modified aging of elite athletes revealed by analysis of epigenetic age markers. Aging (Albany NY). 2018; 10:241–52. https://doi.org/10.18632/aging.101385 [PubMed]

21. Pavanello S, Campisi M, Tona F, Lin CD, Iliceto S. Exploring epigenetic age in response to intensive relaxing training: a pilot study to slow down biological age. Int J Environ Res Public Health. 2019; 16:3074. https://doi.org/10.3390/ijerph16173074 [PubMed]

22. Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, Nemeroff CB, Smith AK, Bradley B, Heim C, Menke A, Lange JF, Brückl T, et al. Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. Genome Biol. 2015; 16:266. https://doi.org/10.1186/s13059-015-0828-5 [PubMed]

23. Wolf EJ, Logue MW, Hayes JP, Sadeh N, Schichman SA, Stone A, Salat DH, Milberg W, McGlinchey R, Miller MW. Accelerated DNA methylation age: associations with PTSD and neural integrity. Psychoneuroendocrinology. 2016; 63:155–62. https://doi.org/10.1016/j.psyneuen.2015.09.020 [PubMed]

24. Moore SR, McEwen LM, Quirt J, Morin A, Mah SM, Barr RG, Boyce WT, Kobor MS. Epigenetic correlates of neonatal contact in humans. Dev Psychopathol. 2017; 29:1517–38. https://doi.org/10.1017/S0954579417001213 [PubMed]

25. Watson NF, Badr MS, Belenky G, Bliwise DL, Buxton OM, Buysse D, Dinges DF, Gangwisch J, Grandner MA, Kushida C, Malhotra RK, Martin JL, Patel SR, et al, and Consensus Conference Panel. Joint consensus statement of the American academy of sleep medicine and sleep research society on the recommended amount of sleep for a healthy adult: methodology and discussion. J Clin Sleep Med. 2015; 11:931–52. https://doi.org/10.5664/jcsm.4950 [PubMed]

26. Nilsson EK, Boström AE, Mwinyi J, Schiöth HB. Epigenomics of total acute sleep deprivation in relation to genome-wide DNA methylation profiles and RNA expression. OMICS. 2016; 20:334–42. https://doi.org/10.1089/omi.2016.0041 [PubMed]

27. Carroll JE, Irwin MR, Levine M, Seeman TE, Absher D, Assimes T, Horvath S. Epigenetic aging and immune senescence in women with insomnia symptoms: findings from the women’s health initiative study. Biol Psychiatry. 2017; 81:136–44. https://doi.org/10.1016/j.biopsych.2016.07.008 [PubMed]

28. Carskadon MA, Chappell KR, Barker DH, Hart AC, Dwyer K, Gredvig-Ardito C, Starr C, McGeary JE. A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults. BMC Res Notes. 2019; 12:583. https://doi.org/10.1186/s13104-019-4633-1 [PubMed]

29. Fahy GM, Brooke RT, Watson JP, Good Z, Vasanawala SS, Maecker H, Leipold MD, Lin DT, Kobor MS, Horvath S. Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell. 2019; 18:e13028. https://doi.org/10.1111/acel.13028 [PubMed]

30. Gensous N, Garagnani P, Santoro A, Giuliani C, Ostan R, Fabbri C, Milazzo M, Gentilini D, di Blasio AM, Pietruszka B, Madej D, Bialecka-Debek A, Brzozowska A, et al. One-year mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project. Geroscience. 2020; 42:687–701. https://doi.org/10.1007/s11357-019-00149-0 [PubMed]

31. Chen L, Dong Y, Bhagatwala J, Raed A, Huang Y, Zhu H. Effects of vitamin D3 supplementation on epigenetic aging in overweight and obese African Americans with suboptimal vitamin D status: a randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2019; 74:91–98. https://doi.org/10.1093/gerona/gly223 [PubMed]

32. Hoyas I, Leon-Sanz M. Nutritional challenges in metabolic syndrome. J Clin Med. 2019; 8:1301. https://doi.org/10.3390/jcm8091301 [PubMed]

33. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003; 23:5293–300. https://doi.org/10.1128/mcb.23.15.5293-5300.2003 [PubMed]

34. Pauwels S, Ghosh M, Duca RC, Bekaert B, Freson K, Huybrechts I, Langie SA, Koppen G, Devlieger R, Godderis L. Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants. Clin Epigenetics. 2017; 9:16. https://doi.org/10.1186/s13148-017-0321-y [PubMed]

35. Sae-Lee C, Corsi S, Barrow TM, Kuhnle GG, Bollati V, Mathers JC, Byun HM. Dietary intervention modifies DNA methylation age assessed by the epigenetic clock. Mol Nutr Food Res. 2018; 62:e1800092. https://doi.org/10.1002/mnfr.201800092 [PubMed]

36. Zhong J, Karlsson O, Wang G, Li J, Guo Y, Lin X, Zemplenyi M, Sanchez-Guerra M, Trevisi L, Urch B, Speck M, Liang L, Coull BA, et al. B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. Proc Natl Acad Sci USA. 2017; 114:3503–08. https://doi.org/10.1073/pnas.1618545114 [PubMed]

37. Niedzwiecki A, Roomi MW, Kalinovsky T, Rath M. Anticancer efficacy of polyphenols and their combinations. Nutrients. 2016; 8:552. https://doi.org/10.3390/nu8090552 [PubMed]

38. Oliai Araghi S, Kiefte-de Jong JC, van Dijk SC, Swart KM, van Laarhoven HW, van Schoor NM, de Groot LC, Lemmens V, Stricker BH, Uitterlinden AG, van der Velde N. Folic acid and vitamin B12 supplementation and the risk of cancer: long-term follow-up of the B vitamins for the prevention of osteoporotic fractures (B-PROOF) trial. Cancer Epidemiol Biomarkers Prev. 2019; 28:275–82. https://doi.org/10.1158/1055-9965.EPI-17-1198 [PubMed]

39. Ebbing M, Bønaa KH, Nygård O, Arnesen E, Ueland PM, Nordrehaug JE, Rasmussen K, Njølstad I, Refsum H, Nilsen DW, Tverdal A, Meyer K, Vollset SE. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA. 2009; 302:2119–26. https://doi.org/10.1001/jama.2009.1622 [PubMed]

40. Tu H, Dinney CP, Ye Y, Grossman HB, Lerner SP, Wu X. Is folic acid safe for non-muscle-invasive bladder cancer patients? an evidence-based cohort study. Am J Clin Nutr. 2018; 107:208–16. https://doi.org/10.1093/ajcn/nqx019 [PubMed]

41. Figueiredo JC, Grau MV, Haile RW, Sandler RS, Summers RW, Bresalier RS, Burke CA, McKeown-Eyssen GE, Baron JA. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst. 2009; 101:432–35. https://doi.org/10.1093/jnci/djp019 [PubMed]

42. Obeid R, Hübner U, Bodis M, Graeber S, Geisel J. Effect of adding b-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers. Nutr Metab Cardiovasc Dis. 2018; 28:411–17. https://doi.org/10.1016/j.numecd.2017.12.006 [PubMed]

43. Lorusso JS, Sviderskiy OA, Labunskyy VM. Emerging omics approaches in aging research. Antioxid Redox Signal. 2018; 29:985–1002. https://doi.org/10.1089/ars.2017.7163 [PubMed]

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